Health & Gastronomy 14/10/2014

Effects of maternal dietary olive oil on diabetic embryopathy

The effects of an olive oil-supplemented diet in pregnant diabetic rats reduced resorption and malformation rates. Embryos and decidua are targets of olive oil benefits on maternal diabetes

Maternal diabetes induces a pro-oxidant/pro-inflammatory intrauterine environment related to the induction of congenital anomalies.

Peroxisome proliferator activated receptors (PPARs) are transcription factors that regulate antioxidant and anti-inflammatory pathways. 

Researchers investigated whether maternal diets supplemented with olive oil, enriched in oleic acid, a PPAR agonist, can regulate the expression of PPAR system genes, levels of lipoperoxidation and activity of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in embryos and decidua from diabetic rats.

The embryos and decidua from diabetic rats showed reduced expression of PPARs and increased concentration of lipoperoxidation, MMPs and TIMPs, whereas the maternal treatments enriched in olive oil increased PPARδ in embryos and PPARγ and PPARγ-coactivator-1α expression in decidua, and increased TIMPs concentrations and decreased lipoperoxidation and MMPs activity in both tissues.

Thus, maternal diets enriched in olive oil can regulate embryonic and decidual PPAR system genes expression and reduce the pro-oxidant/pro-inflammatory environment during rat early organogenesis.


Romina Higa, Sabrina Lorena Roberti, Daniel Musikant, María Belén Mazzucco, Verónica White, Alicia Jawerbaum, Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy, Reproductive Toxicology, Available online 21 September 2014, ISSN 0890-6238

di R. T.